The average train between Rome and Segrate takes 3h 45m and the fastest train takes 3h 35m. There is a train service every few hours from Rome to Segrate. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Rome and Segrate. The earliest departure is at 5:40 AM in the morning, and the last departure from Rome is at 8:05 PM which arrives into Segrate at 11:49 PM. All services require a transfer at Milano Centrale and take an average of 3h 45m. The schedules shown below are for the next available departures.

3h 39m • 1 change

3h 42m • 1 change

3h 39m • 1 change

3h 42m • 1 change

4h 7m • 1 change

3h 47m • 1 change

3h 42m • 1 change

3h 47m • 1 change

4h 7m • 1 change

3h 47m • 1 change

3h 42m • 1 change

3h 47m • 1 change
Want to know about travelling from Rome to Segrate? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Segrate. However, there are services departing from Rome station and arriving at Segrate station via Milano Centrale. The journey, including transfers, takes approximately 3h 45m.
Rome to Segrate train services, operated by ItaloTreno, depart from Roma Termini station.
Rome to Segrate train services, operated by ItaloTreno, arrive at Milano Centrale station.
Book your Rome to Segrate train tickets online with ItaloTreno and Trenord.
The distance between Rome and Segrate is 475 km. The road distance is 592 km.
ItaloTreno operates a train from Roma Termini to Milano Centrale every 30 minutes. Tickets cost €75–150 and the journey takes 3h 5m.