The average train between Rome and Melzo takes 4h 50m and the fastest train takes 3h 34m. There is a train service every few hours from Rome to Melzo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Rome and Melzo. The earliest departure is at 5:38 AM in the morning, and the last departure from Rome is at 8:50 PM which arrives into Melzo at 5:59 AM. All services require a transfer at Milan Centrale and take an average of 4h 50m. The schedules shown below are for the next available departures.

4h 2m • 1 change

4h 9m • 1 change

4h 9m • 1 change

4h 11m • 1 change

3h 51m • 1 change

4h 2m • 1 change

4h 9m • 1 change

4h 9m • 1 change

3h 51m • 1 change

4h 2m • 1 change

4h 9m • 1 change

4h 9m • 1 change
Want to know about travelling from Rome to Melzo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Melzo. However, there are services departing from Rome station and arriving at Melzo station via Milano Centrale. The journey, including transfers, takes approximately 4h 50m.
Rome to Melzo train services, operated by Trenitalia Frecce, depart from Roma Termini station.
Rome to Melzo train services, operated by Trenitalia Frecce, arrive at Milano Centrale station.
Book your Rome to Melzo train tickets online with Trenitalia Frecce and Trenord.
The distance between Rome and Melzo is 470.3 km. The road distance is 582 km.
Trenitalia Frecce operates a train from Roma Termini to Milano Centrale every 30 minutes. Tickets cost €80–170 and the journey takes 3h 9m. ItaloTreno also services this route 4 times a day.