The average train between Rome and Enschede takes 19h 58m and the fastest train takes 15h 57m. The train service runs several times per day from Rome to Enschede. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Rome and Enschede. The earliest departure is at 6:30 AM in the morning, and the last departure from Rome is at 8:05 PM which arrives into Enschede at 8:27 PM. All services require a transfer at Milano Centrale and take an average of 19h 58m. The schedules shown below are for the next available departures.
Arrives next day




20h 17m • 4 changes
Arrives next day




24h 22m • 4 changes




15h 57m • 4 changes
Arrives next day




20h 17m • 4 changes
Arrives next day




24h 22m • 4 changes




15h 57m • 4 changes
Arrives next day




20h 17m • 4 changes
Arrives next day




24h 22m • 4 changes




15h 57m • 4 changes
Arrives next day




20h 17m • 4 changes
Arrives next day




24h 22m • 4 changes




15h 57m • 4 changes
Arrives next day




20h 17m • 4 changes
Arrives next day




24h 22m • 4 changes
Want to know about travelling from Rome to Enschede? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Enschede. However, there are services departing from Rome station and arriving at Enschede station via Milano Centrale. The journey, including transfers, takes approximately 19h 58m.
Rome to Enschede train services, operated by ItaloTreno, depart from Roma Termini station.
Rome to Enschede train services, operated by ItaloTreno, arrive at Enschede station.
Book your Rome to Enschede train tickets online with ItaloTreno, Trenitalia EuroCity and 3 other operators.
The distance between Rome and Enschede is 1,222.3 km. The road distance is 1,614 km.
You can take a train from Roma Termini to Enschede via Milano Centrale, Arth-Goldau, Basel SBB, and Münster Hauptbahnhof in around 17h 29m.