The average train between Prestwick and Brussels takes 9h 34m and the fastest train takes 7h 54m. The train service runs several times per day from Prestwick to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Prestwick and Brussels. The earliest departure is at 5:20 AM in the morning, and the last departure from Prestwick is at 11:10 PM which arrives into Brussels at 1:05 PM. All services require a transfer at Glasgow Central and take an average of 9h 34m. The schedules shown below are for the next available departures.


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Want to know about travelling from Prestwick to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prestwick to Brussels. However, there are services departing from Prestwick station and arriving at Brussels station via Glasgow Central. The journey, including transfers, takes approximately 9h 34m.
Prestwick to Brussels train services, operated by ScotRail, depart from Prestwick Town station.
Prestwick to Brussels train services, operated by ScotRail, arrive at Brussel-Zuid / Bruxelles-Midi station.
Book your Prestwick to Brussels train tickets online with ScotRail, Avanti West Coast and 2 other operators.
The distance between Prestwick and Brussels is 788.7 km. The road distance is 1,073 km.
You can take a train from Prestwick Town to Brussel-Zuid / Bruxelles-Midi via Glasgow Central, London Euston, and London St Pancras Intl in around 9h 9m.