The average train between Prague and Siena takes 22h 4m and the fastest train takes 16h 4m. The train service runs several times per day from Prague to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Prague and Siena. The earliest departure is at 5:35 AM in the morning, and the last departure from Prague is at 5:35 PM which arrives into Siena at 6:40 PM. All services require a transfer at Muenchen Hbf and take an average of 22h 4m. The schedules shown below are for the next available departures.



16h 4m • 3 changes
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27h 3m • 3 changes
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25h 5m • 3 changes



16h 4m • 3 changes
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27h 3m • 3 changes
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25h 5m • 3 changes



16h 4m • 3 changes
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25h 5m • 3 changes
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27h 5m • 3 changes



16h 4m • 3 changes
Arrives next day



25h 5m • 3 changes
Arrives next day



25h 5m • 3 changes



16h 4m • 3 changes
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25h 5m • 3 changes
Arrives next day



25h 5m • 3 changes
Want to know about travelling from Prague to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Siena. However, there are services departing from Prague station and arriving at Siena station via Muenchen Hbf. The journey, including transfers, takes approximately 22h 4m.
Prague to Siena train services, operated by ÖBB EuroCity, depart from Praha Hlavni Nadrazi station.
Prague to Siena train services, operated by ÖBB EuroCity, arrive at Siena station.
Book your Prague to Siena train tickets online with ÖBB EuroCity, Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Prague and Siena is 788.6 km. The road distance is 1,161 km.
You can take a train from Praha Hlavni Nadrazi to Siena via Muenchen Hbf, München Hbf, Verona Porta Nuova, and Firenze S.M.N. in around 17h 6m.