The average train between Prague and Isernia takes 29h 17m and the fastest train takes 27h 46m. The train service runs several times per day from Prague to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Prague and Isernia. The earliest departure is at 4:35 AM at night, and the last departure from Prague is at 6:37 PM which arrives into Isernia at 10:23 PM. All services require a transfer at Wien Hbf and take an average of 29h 17m. The schedules shown below are for the next available departures.
Arrives next day



27h 52m • 3 changes
Arrives next day



30h 46m • 3 changes
Arrives next day



27h 52m • 3 changes
Arrives next day



30h 46m • 3 changes
Arrives next day



27h 52m • 3 changes
Arrives next day



30h 46m • 3 changes
Want to know about travelling from Prague to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Isernia. However, there are services departing from Prague station and arriving at Isernia station via Wien Hbf. The journey, including transfers, takes approximately 29h 17m.
Prague to Isernia train services, operated by České dráhy (ČD), depart from Praha Hlavni Nadrazi station.
Prague to Isernia train services, operated by České dráhy (ČD), arrive at Isernia station.
Book your Prague to Isernia train tickets online with České dráhy (ČD), Railjet and 2 other operators.
The distance between Prague and Isernia is 944.4 km. The road distance is 1,768 km.
You can take a train from Praha Hlavni Nadrazi to Isernia via Wien Hbf, Venezia Mestre, and Roma Termini in around 20h 2m.