The average train between Prague and Debrecen takes 10h 23m and the fastest train takes 10h 18m. The train service runs several times per day from Prague to Debrecen. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Prague and Debrecen. The earliest departure is at 5:37 AM in the morning, and the last departure from Prague is at 1:37 PM which arrives into Debrecen at 12:23 AM. All services require a transfer, and take on average 10h 23m. The schedules shown below are for the next available departures.

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Want to know about travelling from Prague to Debrecen? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Debrecen. However, there are services departing from Prague station and arriving at Debrecen station via Budapest-Nyugati. The journey, including transfers, takes approximately 10h 23m.
Prague to Debrecen train services, operated by ÖBB EuroCity, depart from Praha Hlavni Nadrazi station.
Prague to Debrecen train services, operated by ÖBB EuroCity, arrive at Debrecen station.
The distance between Prague and Debrecen is 598.9 km. The road distance is 826 km.
You can take a train from Praha Hlavni Nadrazi to Debrecen via Budapest-Nyugati in around 10h 8m.