The average train between Perugia and Isernia takes 8h 7m and the fastest train takes 4h 35m. The train service runs several times per day from Perugia to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Perugia and Isernia. The earliest departure is at 6:40 AM in the morning, and the last departure from Perugia is at 5:50 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 8h 7m. The schedules shown below are for the next available departures.

4h 35m • 1 change
6h 31m • 1 changeArrives next day

14h 37m • 1 change
4h 35m • 1 change
6h 31m • 1 changeArrives next day

14h 37m • 1 change
4h 35m • 1 change
6h 31m • 1 changeArrives next day

14h 37m • 1 change
4h 35m • 1 change
6h 31m • 1 changeArrives next day

14h 37m • 1 changeWant to know about travelling from Perugia to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Perugia to Isernia. However, there are services departing from Perugia station and arriving at Isernia station via Roma Termini. The journey, including transfers, takes approximately 8h 7m.
Perugia to Isernia train services, operated by Trenitalia, depart from Perugia station.
Perugia to Isernia train services, operated by Trenitalia, arrive at Isernia station.
Book your Perugia to Isernia train tickets online with Trenitalia and Trenitalia Intercity.
The distance between Perugia and Isernia is 226.7 km. The road distance is 375 km.
You can take a train from Perugia to Isernia via Roma Termini in around 6h 13m.