The average train between Penzance and Slough takes 5h 26m and the fastest train takes 4h 57m. There is a train service every few hours from Penzance to Slough. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Penzance and Slough. The earliest departure is at 5:03 AM in the morning, and the last departure from Penzance is at 9:45 PM which arrives into Slough at 4:58 AM. All services require a transfer, and take on average 5h 26m. The schedules shown below are for the next available departures.

4h 57m • 1 change

5h 27m • 1 change

5h 21m • 1 change

5h 16m • 1 change

4h 57m • 1 change

5h 27m • 1 change

5h 21m • 1 change

5h 16m • 1 change

4h 57m • 1 change

5h 27m • 1 change

5h 21m • 1 change

5h 16m • 1 change

4h 57m • 1 change

5h 27m • 1 change

5h 21m • 1 change

5h 16m • 1 change

4h 57m • 1 change

5h 27m • 1 change

5h 21m • 1 change

5h 16m • 1 change
Want to know about travelling from Penzance to Slough? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Penzance to Slough. However, there are services departing from Penzance station and arriving at Slough station via Reading. The journey, including transfers, takes approximately 5h 26m.
Penzance to Slough train services, operated by Great Western Railway (GWR), depart from Penzance station.
Penzance to Slough train services, operated by Great Western Railway (GWR), arrive at Reading station.
Book your Penzance to Slough train tickets online with Great Western Railway (GWR) and Elizabeth Line (TfL).
The distance between Penzance and Slough is 380 km. The road distance is 458 km.
Great Western Railway (GWR) operates a train from Penzance to Reading every 2 hours. Tickets cost £120–230 and the journey takes 4h 43m.