The average train between Milan and Nyon takes 4h 30m and the fastest train takes 4h 23m. The train service runs several times per day from Milan to Nyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Milan and Nyon. The earliest departure is at 8:10 AM in the morning, and the last departure from Milan is at 7:10 PM which arrives into Nyon at 12:04 AM. All services require a transfer, and take on average 4h 30m. The schedules shown below are for the next available departures.

4h 24m • 1 change

4h 24m • 1 change

4h 24m • 1 change

4h 23m • 1 change

4h 24m • 1 change

4h 24m • 1 change

4h 24m • 1 change
Arrives next day

4h 54m • 1 change

4h 24m • 1 change

4h 24m • 1 change
Arrives next day

4h 54m • 1 change
Want to know about travelling from Milan to Nyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan to Nyon. However, there are services departing from Milan station and arriving at Nyon station via Lausanne. The journey, including transfers, takes approximately 4h 30m.
Milan to Nyon train services, operated by Trenitalia EuroCity, depart from Milano Centrale station.
Milan to Nyon train services, operated by Trenitalia EuroCity, arrive at Lausanne station.
Book your Milan to Nyon train tickets online with Trenitalia EuroCity and Swiss Federal Railways (SBB CFF FFS).
The distance between Milan and Nyon is 250 km. The road distance is 342 km.
Trenitalia EuroCity operates a train from Milano Centrale to Lausanne 3 times a day. Tickets cost CHF 60–110 and the journey takes 3h 38m.