The average train between Milan and Iselle takes 2h 56m and the fastest train takes 2h 8m. The train service runs several times per day from Milan to Iselle. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Milan and Iselle. The earliest departure is at 8:10 AM in the morning, and the last departure from Milan is at 7:10 PM which arrives into Iselle at 11:18 PM. All services require a transfer, and take on average 2h 56m. The schedules shown below are for the next available departures.

2h 8m • 1 change

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2h 13m • 1 change

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3h 8m • 1 change

2h 13m • 1 change

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Want to know about travelling from Milan to Iselle? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan to Iselle. However, there are services departing from Milan station and arriving at Iselle station via Domodossola. The journey, including transfers, takes approximately 2h 56m.
Milan to Iselle train services, operated by Trenitalia EuroCity, depart from Milano Centrale station.
Milan to Iselle train services, operated by Trenitalia EuroCity, arrive at Domodossola station.
The distance between Milan and Iselle is 112.9 km. The road distance is 137 km.
Trenitalia EuroCity operates a train from Milano Centrale to Domodossola every 4 hours. Tickets cost €30–75 and the journey takes 1h 33m.