The average train between Mendrisio and Rome takes 5h 46m and the fastest train takes 4h 37m. The train service runs several times per day from Mendrisio to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Mendrisio and Rome. The earliest departure is at 7:18 AM in the morning, and the last departure from Mendrisio is at 9:18 PM which arrives into Rome at 9:15 AM. All services require a transfer, and take on average 5h 46m. The schedules shown below are for the next available departures.
Arrives next day

5h 57m • 1 change
Arrives next day

11h 57m • 1 change

4h 47m • 1 change

5h 42m • 1 change

5h 2m • 1 change

5h 42m • 1 change

4h 47m • 1 change

5h 7m • 1 change

5h 2m • 1 change

5h 2m • 1 change

4h 47m • 1 change

5h 7m • 1 change

5h 2m • 1 change

5h 2m • 1 change

4h 47m • 1 change

5h 7m • 1 change

5h 2m • 1 change

5h 2m • 1 change
Want to know about travelling from Mendrisio to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mendrisio to Rome. However, there are services departing from Mendrisio station and arriving at Rome station via Milano Centrale. The journey, including transfers, takes approximately 5h 46m.
Mendrisio to Rome train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Mendrisio station.
Mendrisio to Rome train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Roma Termini station.
The distance between Mendrisio and Rome is 523.4 km. The road distance is 619 km.
You can take a train from Mendrisio to Roma Termini via Milano Centrale in around 4h 14m.