Train Mendrisio to Rome from €126 | Tickets & Timetables

Trip Overview

The average train between Mendrisio and Rome takes 6h 2m and the fastest train takes 4h 7m. There is a train service every few hours from Mendrisio to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 2m
Duration: 619 km
Distance: €126
Average price: Hourly
Frequency

Train

best

Take the train from Mendrisio to Milano Centraletrain Re80
Take the train from Milano Centrale to Roma Terminitrain Fr / ...

4h 27m

€92–221

Mendrisio to Rome train times

Trains run hourly between Mendrisio and Rome. The earliest departure is at 6:18 AM in the morning, and the last departure from Mendrisio is at 9:18 PM which arrives into Rome at 9:04 AM. All services require a transfer, and take on average 6h 2m. The schedules shown below are for the next available departures.

Departing Thursday, July 2, 2026

11:18 AM → 4:15 PM
4h 57m • 1 change
12:18 PM → 4:40 PM
4h 22m • 1 change
1:18 PM → 5:40 PM
4h 22m • 1 change
2:18 PM → 6:40 PM
4h 22m • 1 change
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Departing Friday, July 3, 2026

6:18 AM → 10:41 AM
4h 23m • 1 change
7:18 AM → 11:41 AM
4h 23m • 1 change
8:18 AM → 12:39 PM
4h 21m • 1 change
9:18 AM → 2:10 PM
4h 52m • 1 change
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Departing Saturday, July 4, 2026

6:18 AM → 10:41 AM
4h 23m • 1 change
7:18 AM → 11:41 AM
4h 23m • 1 change
8:18 AM → 12:39 PM
4h 21m • 1 change
9:18 AM → 2:10 PM
4h 52m • 1 change
Show more

Departing Sunday, July 5, 2026

6:18 AM → 10:41 AM
4h 23m • 1 change
7:18 AM → 11:41 AM
4h 23m • 1 change
8:18 AM → 12:39 PM
4h 21m • 1 change
9:18 AM → 2:10 PM
4h 52m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Mendrisio to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.