Train Mendrisio to Rome from €115 | Tickets & Timetables

Trip Overview

The average train between Mendrisio and Rome takes 5h 30m and the fastest train takes 4h 42m. There is a train service every few hours from Mendrisio to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 30m
Duration: 639 km
Distance: €115
Average price: Hourly
Frequency

Train

best

Take the train from Mendrisio to Milano Centraletrain Re80
Take the train from Milano Centrale to Roma Terminitrain 9995 / ...

4h 19m

€96–209

Mendrisio to Rome train times

Trains run hourly between Mendrisio and Rome. The earliest departure is at 6:18 AM in the morning, and the last departure from Mendrisio is at 9:18 PM which arrives into Rome at 9:19 AM. All services require a transfer, and take on average 5h 30m. The schedules shown below are for the next available departures.

Departing Wednesday, May 6, 2026

6:18 AM → 11:00 AM
4h 42m • 1 change
7:18 AM → 12:19 PM
5h 1m • 1 change
8:18 AM → 1:24 PM
5h 6m • 1 change
9:18 AM → 2:30 PM
5h 12m • 1 change
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Departing Thursday, May 7, 2026

6:18 AM → 11:00 AM
4h 42m • 1 change
7:18 AM → 12:19 PM
5h 1m • 1 change
8:18 AM → 1:24 PM
5h 6m • 1 change
9:18 AM → 2:30 PM
5h 12m • 1 change
Show more

Departing Friday, May 8, 2026

6:18 AM → 11:00 AM
4h 42m • 1 change
7:18 AM → 12:19 PM
5h 1m • 1 change
8:18 AM → 1:24 PM
5h 6m • 1 change
9:18 AM → 2:30 PM
5h 12m • 1 change
Show more

Departing Saturday, May 9, 2026

6:18 AM → 11:00 AM
4h 42m • 1 change
7:18 AM → 12:19 PM
5h 1m • 1 change
8:18 AM → 1:24 PM
5h 6m • 1 change
9:18 AM → 2:30 PM
5h 12m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Mendrisio to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.