The average train between Mendrisio and Brussels takes 13h 9m and the fastest train takes 11h 22m. The train service runs several times per day from Mendrisio to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mendrisio and Brussels. The earliest departure is at 5:34 AM in the morning, and the last departure from Mendrisio is at 9:41 PM which arrives into Brussels at 11:26 AM. All services require a transfer at Lugano and take an average of 13h 9m. The schedules shown below are for the next available departures.



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11h 22m • 3 changesWant to know about travelling from Mendrisio to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mendrisio to Brussels. However, there are services departing from Lugano station and arriving at Brussels-Nord station via Basel SBB station and Frankfurt station. The journey, including transfers, takes approximately 13h 9m.
Mendrisio to Brussels train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Lugano station.
Mendrisio to Brussels train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Brussels-Nord station.
Book your Mendrisio to Brussels train tickets online with Omio.
The distance between Mendrisio and Brussels is 650.9 km. The road distance is 812 km.
You can take a train from Mendrisio to Brussels-Nord via Lugano, Basel SBB, and Frankfurt in around 11h 44m.