The average train between Mendrisio and Brussels takes 13h 32m and the fastest train takes 10h 14m. The train service runs several times per day from Mendrisio to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Mendrisio and Brussels. The earliest departure is at 5:34 AM in the morning, and the last departure from Mendrisio is at 9:41 PM which arrives into Brussels at 5:00 PM. All services require a transfer at Lugano and take an average of 13h 32m. The schedules shown below are for the next available departures.





11h 26m • 5 changes





13h 53m • 5 changes





10h 34m • 5 changes
Arrives next day





23h 19m • 5 changes





11h 19m • 5 changes





10h 36m • 5 changes
Arrives next day





23h 19m • 5 changes





10h 14m • 5 changes





11h 5m • 5 changes





11h 5m • 5 changes
Arrives next day





20h 43m • 5 changes





10h 14m • 5 changes





11h 17m • 5 changes





11h 5m • 5 changes
Arrives next day





20h 43m • 5 changes
Want to know about travelling from Mendrisio to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mendrisio to Brussels. However, there are services departing from Mendrisio station and arriving at Brussels station via Basel SBB. The journey, including transfers, takes approximately 13h 32m.
Mendrisio to Brussels train services, operated by Trenord, depart from Lugano station.
Mendrisio to Brussels train services, operated by Trenord, arrive at Brussel-Zuid / Bruxelles-Midi station.
Book your Mendrisio to Brussels train tickets online with Trenord, Swiss Federal Railways (SBB CFF FFS) and 3 other operators.
The distance between Mendrisio and Brussels is 650.9 km. The road distance is 1,159 km.
You can take a train from Mendrisio to Brussel-Zuid / Bruxelles-Midi via Lugano, Basel SBB, Basel SBB, Saint-Louis, St Louis, Strasbourg, Strasbourg Bahnhof, Paris l'Est, and Paris Nord in around 11h 17m.