The average train between Mainz and Meschede takes 4h 50m and the fastest train takes 4h 19m. There is a train service every few hours from Mainz to Meschede. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Meschede. The earliest departure is at 12:01 AM at night, and the last departure from Mainz is at 9:20 PM which arrives into Meschede at 2:38 AM. All services require a transfer, and take on average 4h 50m. The schedules shown below are for the next available departures.

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4h 21m • 1 changeWant to know about travelling from Mainz to Meschede? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Meschede. However, there are services departing from Mainz Hbf station and arriving at Meschede, Bahnhof station via Dortmund Hbf station. The journey, including transfers, takes approximately 4h 50m.
Mainz to Meschede train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz Hbf station.
Mainz to Meschede train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Meschede, Bahnhof station.
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The distance between Mainz and Meschede is 151.9 km. The road distance is 210 km.
You can take a train from Mainz Hbf to Meschede, Bahnhof via Dortmund Hbf in around 4h 32m.