The average train between Mainz and Brindisi takes 22h 54m and the fastest train takes 16h 52m. The train service runs several times per day from Mainz to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Mainz and Brindisi. The earliest departure is at 5:40 AM in the morning, and the last departure from Mainz is at 11:08 PM which arrives into Brindisi at 10:32 PM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 22h 54m. The schedules shown below are for the next available departures.





16h 52m • 5 changes
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26h 15m • 5 changes
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25h 31m • 5 changes
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23h 17m • 5 changes





16h 52m • 5 changes
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26h 15m • 5 changes
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25h 31m • 5 changes
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23h 17m • 5 changes
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26h 15m • 5 changes
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25h 31m • 5 changes
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23h 17m • 5 changes





16h 52m • 5 changes
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26h 15m • 5 changes
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25h 31m • 5 changes
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23h 17m • 5 changes





16h 52m • 5 changes
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26h 15m • 5 changes
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21h 7m • 5 changes
Want to know about travelling from Mainz to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Brindisi. However, there are services departing from Mainz station and arriving at Brindisi station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 22h 54m.
Mainz to Brindisi train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz, Hauptbahnhof station.
Mainz to Brindisi train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Brindisi station.
Book your Mainz to Brindisi train tickets online with Deutsche Bahn Intercity (DB IC), Swiss Federal Railways (SBB CFF FFS) and 3 other operators.
The distance between Mainz and Brindisi is 1,282.9 km. The road distance is 1,620 km.
You can take a train from Mainz, Hauptbahnhof to Brindisi via Mannheim, Hauptbahnhof, Basel SBB, Lugano, Milano Centrale, and Reggio Emilia Av in around 18h 15m.