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Mainz to Brindisi trains

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Trip Overview

The average train between Mainz and Brindisi takes 25h 39m and the fastest train takes 21h 10m. The train service runs several times per day from Mainz to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

25h 39m
Duration
1,648 km
Distance
€355
Average price
3 times a day
Frequency

Mainz to Brindisi train times

Trains run 3 times a day between Mainz and Brindisi. The earliest departure is at 1:14 PM in the afternoon, and the last departure from Mainz is at 9:14 PM which arrives into Brindisi at 6:24 PM. All services require a transfer at Frankfurt and take an average of 25h 39m. The schedules shown below are for the next available departures.

Departing Friday, October 30, 2026

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    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce26h 14m • 5 changes
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    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce23h 10m • 5 changes

Departing Saturday, October 31, 2026

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    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce26h 14m • 5 changes
  •  → 

    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce21h 10m • 5 changes

Departing Sunday, November 1, 2026

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    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce26h 14m • 5 changes
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    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce25h 10m • 5 changes
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    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce26h 15m • 5 changes

Departing Monday, November 2, 2026

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    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce26h 14m • 5 changes
  •  → 

    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce25h 10m • 5 changes
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    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce26h 15m • 5 changes

Departing Tuesday, November 3, 2026

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    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce26h 14m • 5 changes
  •  → 

    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce25h 10m • 5 changes
  •  → 

    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce26h 15m • 5 changes

Departing Wednesday, November 4, 2026

  •  → 

    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce26h 14m • 5 changes
  •  → 

    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce25h 10m • 5 changes
  •  → 

    Arrives next day

    vlexxDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)ItaloTrenoTrenitalia Frecce26h 15m • 5 changes

Frequently asked questions

Want to know about travelling from Mainz to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mainz to Brindisi.ExpandLaunch map view
  • Distance: 1,648 km
  • Duration: 25h 39m

What companies run services between Mainz, Germany and Brindisi, Italy?

You can take a train from Mainz, Römisches Theater to Brindisi Stazione Centrale via Frankfurt, Basel SBB, Lugano, Milano Centrale, and Reggio Emilia Av in around 19h 8m.

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