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Mainz to Brindisi trains

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Trip Overview

The average train between Mainz and Brindisi takes 22h 4m and the fastest train takes 16h 52m. The train service runs several times per day from Mainz to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

22h 4m
Duration
1,620 km
Distance
€333
Average price
4 times a day
Frequency

Train

best
  1. Take the train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhoftrain train 55 / ...
  2. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train 12 / ...
  3. Take the train from Basel SBB to Luganotrain train Ec
  4. Take the train from Lugano to Milano Centraletrain train
  5. Take the train from Milano Centrale to Reggio Emilia Avtrain train Fr
  6. Take the train from Reggio Emilia Av to Brindisitrain train Fr
18h 21m
€205–532

Mainz to Brindisi train times

Trains run 4 times a day between Mainz and Brindisi. The earliest departure is at 1:38 AM at night, and the last departure from Mainz is at 11:08 PM which arrives into Brindisi at 8:27 PM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 22h 4m. The schedules shown below are for the next available departures.

Departing Saturday, October 10, 2026

  •  → 

    Deutsche Bahn Regio (DB Regional)Nederlandse Spoorwegen (NS)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce18h 49m • 5 changes

  •  → 

    Deutsche Bahn Intercity (DB IC)Deutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce16h 52m • 5 changes

  •  → 

    Arrives next day

    SüwexDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce26h 15m • 5 changes

  •  → 

    Arrives next day

    SüwexDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce21h 7m • 5 changes

Departing Sunday, October 11, 2026

  •  → 

    Deutsche Bahn Regio (DB Regional)Nederlandse Spoorwegen (NS)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce18h 49m • 5 changes

  •  → 

    Deutsche Bahn Intercity (DB IC)Deutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce16h 52m • 5 changes

  •  → 

    Arrives next day

    SüwexDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce26h 15m • 5 changes

  •  → 

    Arrives next day

    SüwexDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce25h 7m • 5 changes
  • Show more

Departing Monday, October 12, 2026

  •  → 

    Deutsche Bahn Intercity (DB IC)Deutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce16h 52m • 5 changes

  •  → 

    Arrives next day

    SüwexDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce26h 15m • 5 changes

  •  → 

    Arrives next day

    Deutsche Bahn Regio (DB Regional)Deutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce25h 31m • 5 changes

  •  → 

    Arrives next day

    Deutsche Bahn Regio (DB Regional)Nederlandse Spoorwegen (NS)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce21h 19m • 5 changes

Departing Tuesday, October 13, 2026

  •  → 

    Deutsche Bahn Intercity (DB IC)Deutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce16h 52m • 5 changes

  •  → 

    Arrives next day

    SüwexDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce26h 15m • 5 changes

  •  → 

    Arrives next day

    Deutsche Bahn Regio (DB Regional)Deutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce25h 31m • 5 changes

  •  → 

    Arrives next day

    Deutsche Bahn Regio (DB Regional)Nederlandse Spoorwegen (NS)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce21h 19m • 5 changes

Departing Wednesday, October 14, 2026

  •  → 

    Deutsche Bahn Intercity (DB IC)Deutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce16h 52m • 5 changes

  •  → 

    Arrives next day

    SüwexDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce26h 15m • 5 changes

  •  → 

    Arrives next day

    Deutsche Bahn Regio (DB Regional)Deutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce25h 31m • 5 changes

  •  → 

    Arrives next day

    Deutsche Bahn Regio (DB Regional)Nederlandse Spoorwegen (NS)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce21h 19m • 5 changes

Departing Thursday, October 15, 2026

  •  → 

    Deutsche Bahn Intercity (DB IC)Deutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce16h 52m • 5 changes

  •  → 

    Arrives next day

    SüwexDeutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce26h 15m • 5 changes

  •  → 

    Arrives next day

    Deutsche Bahn Regio (DB Regional)Deutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce25h 31m • 5 changes

  •  → 

    Arrives next day

    Deutsche Bahn Regio (DB Regional)Nederlandse Spoorwegen (NS)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce21h 19m • 5 changes

Departing Friday, October 16, 2026

  •  → 

    Deutsche Bahn Intercity (DB IC)Deutsche Bahn Intercity (DB IC)Swiss Federal Railways (SBB CFF FFS)Swiss Federal Railways (SBB CFF FFS)Trenitalia FrecceTrenitalia Frecce16h 52m • 5 changes

Frequently asked questions

Want to know about travelling from Mainz to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mainz to Brindisi.ExpandLaunch map view
  • Distance: 1,620.4 km
  • Duration: 22h 4m

What companies run services between Mainz, Germany and Brindisi, Italy?

You can take a train from Mainz, Hauptbahnhof to Brindisi via Mannheim, Hauptbahnhof, Basel SBB, Lugano, Milano Centrale, and Reggio Emilia Av in around 18h 21m.

Operators