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Lyon to Isernia trains

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Trip Overview

The average train between Lyon and Isernia takes 17h 23m and the fastest train takes 10h 24m. The train service runs several times per day from Lyon to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

17h 23m
Duration
1,211 km
Distance
€169
Average price
Twice daily
Frequency

Lyon to Isernia train times

Trains run twice daily between Lyon and Isernia. The earliest departure is at 8:32 AM in the morning, and the last departure from Lyon is at 5:23 PM which arrives into Isernia at 3:23 PM. All services require a transfer at Milano Centrale and take an average of 17h 23m. The schedules shown below are for the next available departures.

Departing Tuesday, November 3, 2026

  •  → 

    TrenitaliaItaloTrenoTrenitalia13h 54m • 2 changes
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    Arrives next day

    TrenitaliaItaloTrenoTrenitalia22h • 2 changes

Departing Wednesday, November 4, 2026

  •  → 

    TrenitaliaItaloTrenoTrenitalia13h 54m • 2 changes
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    Arrives next day

    TrenitaliaItaloTrenoTrenitalia22h • 2 changes

Departing Thursday, November 5, 2026

  •  → 

    TrenitaliaItaloTrenoTrenitalia13h 54m • 2 changes
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    Arrives next day

    TrenitaliaItaloTrenoTrenitalia22h • 2 changes

Departing Friday, November 6, 2026

  •  → 

    TrenitaliaItaloTrenoTrenitalia13h 54m • 2 changes
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    Arrives next day

    TrenitaliaItaloTrenoTrenitalia22h • 2 changes

Departing Saturday, November 7, 2026

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    TrenitaliaItaloTrenoTrenitalia12h 55m • 2 changes
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    Arrives next day

    TrenitaliaItaloTrenoTrenitalia23h 17m • 2 changes

Departing Sunday, November 8, 2026

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    TrenitaliaItaloTrenoTrenitalia10h 24m • 2 changes
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    Arrives next day

    TrenitaliaItaloTrenoTrenitalia22h • 2 changes

Departing Monday, November 9, 2026

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    TrenitaliaItaloTrenoTrenitalia13h 54m • 2 changes

Frequently asked questions

Want to know about travelling from Lyon to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lyon to Isernia.ExpandLaunch map view
  • Distance: 1,211 km
  • Duration: 17h 23m

What companies run services between Lyon, France and Isernia, Italy?

You can take a train from Lyon Part Dieu to Isernia via Milano Centrale and Roma Termini in around 11h 12m.

Operators