The average train between Lyon and Domodossola takes 7h 33m and the fastest train takes 5h 33m. The train service runs several times per day from Lyon to Domodossola. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Lyon and Domodossola. The earliest departure is at 10:38 AM in the morning, and the last departure from Lyon is at 8:38 PM which arrives into Domodossola at 8:11 AM. All services require a transfer, and take on average 7h 33m. The schedules shown below are for the next available departures.

5h 33m • 1 change

5h 36m • 1 change
Arrives next day

11h 33m • 1 change

5h 33m • 1 change

6h 33m • 1 change
Arrives next day

13h 33m • 1 change

5h 33m • 1 change

6h 33m • 1 change
Arrives next day

11h 33m • 1 change

5h 33m • 1 change

5h 36m • 1 change
Arrives next day

11h 33m • 1 change

5h 33m • 1 change

5h 36m • 1 change
Arrives next day

11h 33m • 1 change
Want to know about travelling from Lyon to Domodossola? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Lyon to Domodossola. However, there are services departing from Lyon station and arriving at Domodossola station via Geneve. The journey, including transfers, takes approximately 7h 33m.
Lyon to Domodossola train services, operated by Société Nationale des Chemins de fer Français (SNCF), depart from Lyon Part Dieu station.
Lyon to Domodossola train services, operated by Société Nationale des Chemins de fer Français (SNCF), arrive at Domodossola station.
Book your Lyon to Domodossola train tickets online with Société Nationale des Chemins de fer Français (SNCF), Swiss Federal Railways (SBB CFF FFS) and TGV inOui.
The distance between Lyon and Domodossola is 269.6 km. The road distance is 404 km.
You can take a train from Lyon Part Dieu to Domodossola via Genève in around 5h 43m.