The average train between Lyon and Brno takes 24h 12m and the fastest train takes 20h 40m. The train service runs several times per day from Lyon to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Lyon and Brno. The earliest departure is at 8:32 AM in the morning, and the last departure from Lyon is at 6:00 PM which arrives into Brno at 8:41 PM. All services require a transfer at Strasbourg and take an average of 24h 12m. The schedules shown below are for the next available departures.
Arrives next day





22h 9m • 5 changes
Arrives next day





22h 11m • 5 changes
Arrives next day





26h 41m • 5 changes
Arrives next day





22h 9m • 5 changes
Arrives next day





23h 40m • 5 changes
Arrives next day





26h 41m • 5 changes
Arrives next day





22h 9m • 5 changes
Arrives next day





24h 34m • 5 changes
Arrives next day





26h 41m • 5 changes
Want to know about travelling from Lyon to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Lyon to Brno. However, there are services departing from Lyon station and arriving at Brno station via Strasbourg. The journey, including transfers, takes approximately 24h 12m.
Lyon to Brno train services, operated by TGV inOui, depart from Lyon Part Dieu station.
Lyon to Brno train services, operated by TGV inOui, arrive at Brno Hlavni Nadrazi station.
Book your Lyon to Brno train tickets online with TGV inOui, Deutsche Bahn Intercity (DB IC) and 6 other operators.
The distance between Lyon and Brno is 962.2 km. The road distance is 1,505 km.
You can take a train from Lyon Part Dieu to Brno Hlavni Nadrazi via Strasbourg, Strasbourg Bahnhof, Hauptbahnhof, München Hbf, Salzburg Hauptbahnhof, Salzburg Hbf, and Wien Hbf in around 16h 1m.