The average train between Lucerne and Mendrisio takes 2h 2m and the fastest train takes 2h. The train service runs several times per day from Lucerne to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Lucerne and Mendrisio. The earliest departure is at 6:18 AM in the morning, and the last departure from Lucerne is at 10:18 PM which arrives into Mendrisio at 12:27 AM. All services require a transfer, and take on average 2h 2m. The schedules shown below are for the next available departures.

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Want to know about travelling from Lucerne to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Lucerne to Mendrisio. However, there are services departing from Lucerne station and arriving at Mendrisio station via Lugano. The journey, including transfers, takes approximately 2h 2m.
Lucerne to Mendrisio train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Luzern station.
Lucerne to Mendrisio train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Lugano station.
Book your Lucerne to Mendrisio train tickets online with Swiss Federal Railways (SBB CFF FFS).
The distance between Lucerne and Mendrisio is 141.2 km. The road distance is 178 km.
Swiss Federal Railways (SBB CFF FFS) operates a train from Luzern to Lugano every 3 hours. Tickets cost CHF 50–160 and the journey takes 1h 40m.