The average train between Leipzig and Neu-Isenburg takes 3h 35m and the fastest train takes 3h 22m. There is a train service every few hours from Leipzig to Neu-Isenburg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Leipzig and Neu-Isenburg. The earliest departure is at 5:28 AM in the morning, and the last departure from Leipzig is at 10:58 PM which arrives into Neu-Isenburg at 5:41 AM. All services require a transfer at Frankfurt and take an average of 3h 35m. The schedules shown below are for the next available departures.

3h 23m • 1 change

3h 29m • 1 change
Arrives next day

3h 22m • 1 change
Arrives next day

6h 43m • 1 change

3h 43m • 1 change

3h 22m • 1 change

3h 44m • 1 change

3h 22m • 1 change

3h 28m • 1 change

3h 22m • 1 change

3h 34m • 1 change

3h 22m • 1 change

3h 43m • 1 change

3h 22m • 1 change

3h 44m • 1 change

3h 22m • 1 change
Want to know about travelling from Leipzig to Neu-Isenburg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Leipzig to Neu-Isenburg. However, there are services departing from Leipzig station and arriving at Neu-Isenburg station via Frankfurt. The journey, including transfers, takes approximately 3h 35m.
Leipzig to Neu-Isenburg train services, operated by Deutsche Bahn Intercity (DB IC), depart from Leipzig Hbf station.
Leipzig to Neu-Isenburg train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Frankfurt station.
The distance between Leipzig and Neu-Isenburg is 296.1 km. The road distance is 379 km.
Deutsche Bahn Intercity (DB IC) operates a train from Leipzig Hbf to Frankfurt hourly. Tickets cost €70–170 and the journey takes 3h 10m.