The average train between Isère and Lyon takes 2h 19m and the fastest train takes 1h 45m. There is a train service every few hours from Isère to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Isère and Lyon. The earliest departure is at 6:18 AM in the morning, and the last departure from Isère is at 9:18 PM which arrives into Lyon at 6:44 AM. All services require a transfer, and take on average 2h 19m. The schedules shown below are for the next available departures.

2h 26m • 1 change

2h 4m • 1 change

2h 25m • 1 change

1h 57m • 1 change

1h 57m • 1 change

2h 4m • 1 change

1h 48m • 1 change

1h 48m • 1 change

2h 26m • 1 change

1h 48m • 1 change

2h 4m • 1 change

2h 4m • 1 change
Want to know about travelling from Isère to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isère to Lyon. However, there are services departing from Isère station and arriving at Lyon station via Lyon Part Dieu. The journey, including transfers, takes approximately 2h 19m.
Isère to Lyon train services, operated by Société Nationale des Chemins de fer Français (SNCF), depart from Grenoble station.
Isère to Lyon train services, operated by Société Nationale des Chemins de fer Français (SNCF), arrive at Lyon Part Dieu station.
Book your Isère to Lyon train tickets online with Société Nationale des Chemins de fer Français (SNCF) and Zou! Lignes Express Régionales.
The distance between Isère and Lyon is 100.5 km. The road distance is 142 km.
Société Nationale des Chemins de fer Français (SNCF) operates a train from Grenoble to Lyon Part Dieu every 30 minutes. Tickets cost €21–45 and the journey takes 1h 23m.