The average train between Issoire and Lyon takes 3h 57m and the fastest train takes 2h 55m. The train service runs several times per day from Issoire to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Issoire and Lyon. The earliest departure is at 5:02 AM in the morning, and the last departure from Issoire is at 9:59 PM which arrives into Lyon at 8:35 AM. All services require a transfer, and take on average 3h 57m. The schedules shown below are for the next available departures.

3h 33m • 1 change

2h 55m • 1 change

3h 4m • 1 change

4h 37m • 1 change

3h 33m • 1 change

2h 55m • 1 change

3h 4m • 1 change

4h 37m • 1 change

3h 40m • 1 change

4h 37m • 1 change

3h 21m • 1 change

3h 40m • 1 change

3h 40m • 1 change

4h 37m • 1 change

3h 21m • 1 change

3h 40m • 1 change

3h 51m • 1 change

3h 21m • 1 change

3h 40m • 1 change

3h 53m • 1 change

3h 33m • 1 change

2h 55m • 1 change

3h 4m • 1 change

4h 37m • 1 change
Want to know about travelling from Issoire to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Issoire to Lyon. However, there are services departing from Issoire station and arriving at Lyon station via Clermont Ferrand. The journey, including transfers, takes approximately 3h 57m.
Issoire to Lyon train services, operated by Société Nationale des Chemins de fer Français (SNCF), depart from Issoire station.
Issoire to Lyon train services, operated by Société Nationale des Chemins de fer Français (SNCF), arrive at Lyon Part Dieu station.
Book your Issoire to Lyon train tickets online with Société Nationale des Chemins de fer Français (SNCF).
The distance between Issoire and Lyon is 126.3 km. The road distance is 253 km.
You can take a train from Issoire to Lyon Part Dieu via Clermont Ferrand in around 4h 6m.