The average train between Isernia and Brennero takes 17h 21m and the fastest train takes 11h 10m. The train service runs several times per day from Isernia to Brennero. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Isernia and Brennero. The earliest departure is at 8:38 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Brennero at 3:48 PM. All services require a transfer at Roma Termini and take an average of 17h 21m. The schedules shown below are for the next available departures.


11h 10m • 2 changes
Arrives next day


20h 45m • 2 changes
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19h 13m • 2 changes


11h 10m • 2 changes
Arrives next day


20h 45m • 2 changes
Arrives next day


19h 13m • 2 changes


11h 10m • 2 changes
Arrives next day


20h 29m • 2 changes
Arrives next day


19h 13m • 2 changes
Arrives next day


20h 29m • 2 changes
Arrives next day


19h 13m • 2 changes
Want to know about travelling from Isernia to Brennero? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Brennero. However, there are services departing from Isernia station and arriving at Brennero station via Roma Termini. The journey, including transfers, takes approximately 17h 21m.
Isernia to Brennero train services, operated by Trenitalia, depart from Isernia station.
Isernia to Brennero train services, operated by Trenitalia, arrive at Brennero - Brenner station.
Book your Isernia to Brennero train tickets online with Trenitalia, ItaloTreno and Deutsche Bahn Intercity (DB IC).
The distance between Isernia and Brennero is 639.2 km. The road distance is 887 km.
You can take a train from Isernia to Brennero - Brenner via Roma Termini and Verona Porta Nuova in around 10h 25m.