The average train between Holyhead and Southampton takes 5h 36m and the fastest train takes 5h 30m. The train service runs several times per day from Holyhead to Southampton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Holyhead and Southampton. The earliest departure is at 4:44 AM at night, and the last departure from Holyhead is at 5:53 PM which arrives into Southampton at 12:36 AM. All services require a transfer at London Euston and take an average of 5h 36m. The schedules shown below are for the next available departures.


5h 37m • 2 changes


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5h 33m • 2 changes


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5h 53m • 2 changes


5h 46m • 2 changes


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5h 46m • 2 changes
Want to know about travelling from Holyhead to Southampton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Holyhead to Southampton. However, there are services departing from Holyhead station and arriving at Southampton station via London Euston. The journey, including transfers, takes approximately 5h 36m.
Holyhead to Southampton train services, operated by Avanti West Coast, depart from Holyhead station.
Holyhead to Southampton train services, operated by Avanti West Coast, arrive at Southampton Central station.
Book your Holyhead to Southampton train tickets online with Avanti West Coast, London Underground (Tube) and South Western Railway.
The distance between Holyhead and Southampton is 346.7 km. The road distance is 552 km.
You can take a train from Holyhead to Southampton Central via London Euston, Euston station, Waterloo Station, and London Waterloo in around 5h 33m.