The average train between Hesse and Karlsruhe takes 1h 16m and the fastest train takes 1h 12m. There is an hourly train service from Hesse to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Hesse and Karlsruhe. The earliest departure is at 2:11 AM at night, and the last departure from Hesse is at 10:41 PM which arrives into Karlsruhe at 11:59 PM. All services require a transfer, and take on average 1h 16m. The schedules shown below are for the next available departures.

1h 18m • 1 change

1h 12m • 1 change

1h 18m • 1 change

1h 17m • 1 change

1h 49m • 1 change

1h 18m • 1 change

1h 18m • 1 change

1h 21m • 1 change

1h 49m • 1 change

1h 18m • 1 change

1h 18m • 1 change

1h 21m • 1 change
Want to know about travelling from Hesse to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Hesse to Karlsruhe. However, there are services departing from Hesse station and arriving at Karlsruhe station via Karlsruhe Hauptbahnhof. The journey, including transfers, takes approximately 1h 16m.
Hesse to Karlsruhe train services, operated by Deutsche Bahn Regio (DB Regional), depart from Frankfurt station.
Hesse to Karlsruhe train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Karlsruhe Hauptbahnhof station.
The distance between Hesse and Karlsruhe is 183.3 km. The road distance is 140 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Karlsruhe Hauptbahnhof hourly. Tickets cost €25–60 and the journey takes 1h 3m. Süwex also services this route 4 times a day.