The average train between Hamilton and Manchester takes 3h 15m and the fastest train takes 2h 55m. There is a train service every few hours from Hamilton to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Hamilton and Manchester. The earliest departure is at 5:48 AM in the morning, and the last departure from Hamilton is at 8:21 PM which arrives into Manchester at 11:21 PM. All services require a transfer, and take on average 3h 15m. The schedules shown below are for the next available departures.

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Want to know about travelling from Hamilton to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Hamilton to Manchester. However, there are services departing from Hamilton station and arriving at Manchester station via Lancaster. The journey, including transfers, takes approximately 3h 15m.
Hamilton to Manchester train services, operated by Avanti West Coast, depart from Motherwell station.
Hamilton to Manchester train services, operated by Avanti West Coast, arrive at Manchester Oxford Road station.
Book your Hamilton to Manchester train tickets online with Avanti West Coast, TransPennine Express and Northern Trains Limited.
The distance between Hamilton and Manchester is 279.2 km. The road distance is 336 km.
You can take a train from Motherwell to Manchester Oxford Road via Lancaster in around 3h 5m.