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Framingham to Buffalo trains

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Trip Overview

The train between Framingham and Buffalo takes 26h 5m. The train runs, on average, 6 times per week from Framingham to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

26h 5m
Duration
475 mi
Distance
$337
Average price
6 times a week
Frequency

Framingham to Buffalo train times

Trains run 6 times a week between Framingham and Buffalo. The service departs Framingham at 1:25 PM in the afternoon, which arrives into Buffalo at 15:30:00. All services require a transfer, and take on average 26h 5m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

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    Arrives next day

    AmtrakVIA Rail26h 5m • 1 change

Departing Monday, November 9, 2026

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    Arrives next day

    AmtrakVIA Rail26h 5m • 1 change

Departing Tuesday, November 10, 2026

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    Arrives next day

    AmtrakVIA Rail26h 5m • 1 change

Departing Wednesday, November 11, 2026

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    Arrives next day

    AmtrakVIA Rail26h 5m • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    AmtrakVIA Rail26h 5m • 1 change

Departing Friday, November 13, 2026

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    Arrives next day

    AmtrakVIA Rail26h 5m • 1 change

Frequently asked questions

Want to know about travelling from Framingham to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Framingham to Buffalo.ExpandLaunch map view
  • Distance: 474.9 mi
  • Duration: 26h 5m

What companies run services between Framingham, MA, USA and Buffalo, NY, USA?

Amtrak operates a train from Framingham Amtrak to Buffalo Depew Station once daily. Tickets cost $250–400 and the journey takes 11h 4m.

Operators