The average train between Essen and Mosbach takes 4h 4m and the fastest train takes 3h 47m. There is a train service every few hours from Essen to Mosbach. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Essen and Mosbach. The earliest departure is at 6:00 AM in the morning, and the last departure from Essen is at 11:00 PM which arrives into Mosbach at 5:39 AM. All services require a transfer, and take on average 4h 4m. The schedules shown below are for the next available departures.

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4h 19m • 1 changeWant to know about travelling from Essen to Mosbach? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Essen to Mosbach. However, there are services departing from Essen Hbf station and arriving at Mosbach, Bahnhof station via Mannheim, Hauptbahnhof station. The journey, including transfers, takes approximately 4h 4m.
Essen to Mosbach train services, operated by Deutsche Bahn Intercity (DB IC), depart from Essen Hbf station.
Essen to Mosbach train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Mosbach, Bahnhof station.
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The distance between Essen and Mosbach is 278.6 km. The road distance is 352 km.
You can take a train from Essen Hbf to Mosbach, Bahnhof via Mannheim, Hauptbahnhof in around 4h 3m.