The average train between Desio and Rome takes 4h 53m and the fastest train takes 4h 2m. The train service runs several times per day from Desio to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Desio and Rome. The earliest departure is at 6:23 AM in the morning, and the last departure from Desio is at 7:23 PM which arrives into Rome at 9:19 AM. All services require a transfer at niguarda and take an average of 4h 53m. The schedules shown below are for the next available departures.

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4h 2m • 1 changeWant to know about travelling from Desio to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Desio to Rome. However, there are services departing from Milano Centrale station and arriving at Roma Termini station via Roma Termini station. The journey, including transfers, takes approximately 4h 53m.
Desio to Rome train services, operated by Trenitalia Frecce, depart from Milano Centrale station.
Desio to Rome train services, operated by Trenitalia Frecce, arrive at Roma Termini station.
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The distance between Desio and Rome is 490.8 km. The road distance is 587 km.
Trenitalia Frecce operates a train from Milano Centrale to Roma Termini every 30 minutes. Tickets cost €75–130 and the journey takes 3h 4m. ItaloTreno also services this route 4 times a day.