The average train between Como and Isernia takes 8h 55m and the fastest train takes 6h 47m. The train service runs several times per day from Como to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Como and Isernia. The earliest departure is at 8:36 AM in the morning, and the last departure from Como is at 9:36 PM which arrives into Isernia at 11:15 AM. All services require a transfer at Milano Centrale and take an average of 8h 55m. The schedules shown below are for the next available departures.


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12h 51m • 2 changes
Want to know about travelling from Como to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Como to Isernia. However, there are services departing from Como station and arriving at Isernia station via Milano Centrale. The journey, including transfers, takes approximately 8h 55m.
Como to Isernia train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Como S. Giovanni station.
Como to Isernia train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Isernia station.
Book your Como to Isernia train tickets online with Swiss Federal Railways (SBB CFF FFS), Trenitalia Frecce and 2 other operators.
The distance between Como and Isernia is 624.9 km. The road distance is 794 km.
You can take a train from Como S. Giovanni to Isernia via Milano Centrale and Roma Termini in around 7h 16m.