The average train between Chicago and St. Louis (Region) takes 5h and the fastest train takes 4h 46m. The train service runs several times per day from Chicago to St. Louis (Region). The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Chicago and St. Louis (Region). The earliest departure is at 7:15 AM in the morning, and the last departure from Chicago is at 7:10 PM which arrives into St. Louis (Region) at 12:09 AM. All services run direct with no transfers required, and take on average 5h. The schedules shown below are for the next available departures.
Want to know about travelling from Chicago to St. Louis (Region)? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
Yes, there is a direct train departing from Chicago station and arriving at St. Louis (Region) station. Services depart 5 times a day, and operate Once daily. The journey takes approximately 5h.
Chicago to St. Louis (Region) train services, operated by Amtrak, depart from Chicago Union Station.
Chicago to St. Louis (Region) train services, operated by Amtrak, arrive at St. Louis station.
Book your Chicago to St. Louis (Region) train tickets online with Amtrak.
The distance between Chicago and St. Louis (Region) is 421.9 km. The road distance is 452 km.
Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $75–170 and the journey takes 4h 46m.
