The average train between Cambridge and Manchester takes 4h 21m and the fastest train takes 3h 39m. There is a train service every few hours from Cambridge to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Cambridge and Manchester. The earliest departure is at 5:15 AM in the morning, and the last departure from Cambridge is at 9:00 PM which arrives into Manchester at 12:39 AM. All services require a transfer, and take on average 4h 21m. The schedules shown below are for the next available departures.

4h 4m • 1 change

4h 21m • 1 change

4h 22m • 1 change

4h 19m • 1 change

4h 4m • 1 change

4h 21m • 1 change

4h 22m • 1 change

4h 19m • 1 change

4h 4m • 1 change

4h 21m • 1 change

4h 22m • 1 change

4h 19m • 1 change
Want to know about travelling from Cambridge to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Cambridge to Manchester. However, there are services departing from Cambridge station and arriving at Manchester station via Nuneaton. The journey, including transfers, takes approximately 4h 21m.
Cambridge to Manchester train services, operated by Cross Country, depart from Cambridge station.
Cambridge to Manchester train services, operated by Cross Country, arrive at Manchester Piccadilly station.
Book your Cambridge to Manchester train tickets online with Cross Country and Avanti West Coast.
The distance between Cambridge and Manchester is 212.8 km. The road distance is 324 km.
You can take a train from Cambridge to Manchester Piccadilly via Nuneaton in around 4h 1m.