The average train between Brno and Pilsen takes 4h 44m and the fastest train takes 4h 12m. There is a train service every few hours from Brno to Pilsen. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Brno and Pilsen. The earliest departure is at 3:10 AM at night, and the last departure from Brno is at 9:46 PM which arrives into Pilsen at 6:37 AM. All services require a transfer, and take on average 4h 44m. The schedules shown below are for the next available departures.

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4h 12m • 1 changeWant to know about travelling from Brno to Pilsen? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Brno to Pilsen. However, there are services departing from Brno station and arriving at Pilsen station via Praha Hlavni Nadrazi. The journey, including transfers, takes approximately 4h 44m.
Brno to Pilsen train services, operated by Railjet, depart from Brno Hlavni Nadrazi station.
Brno to Pilsen train services, operated by Railjet, arrive at Plzen Hlavni Nadrazi station.
Book your Brno to Pilsen train tickets online with Railjet, České dráhy (ČD) and 4 other operators.
The distance between Brno and Pilsen is 241.3 km. The road distance is 352 km.
You can take a train from Brno Hlavni Nadrazi to Plzen Hlavni Nadrazi via Praha Hlavni Nadrazi in around 4h 20m.