The average train between Brno and Most takes 5h 32m and the fastest train takes 4h 45m. The train service runs several times per day from Brno to Most. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Brno and Most. The earliest departure is at 3:10 AM at night, and the last departure from Brno is at 9:46 PM which arrives into Most at 7:31 AM. All services require a transfer, and take on average 5h 32m. The schedules shown below are for the next available departures.

4h 45m • 1 change

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Arrives next day

9h 45m • 1 change

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6h 21m • 1 change

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5h 15m • 1 change
Want to know about travelling from Brno to Most? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Brno to Most. However, there are services departing from Brno station and arriving at Most station via Praha Hlavni Nadrazi. The journey, including transfers, takes approximately 5h 32m.
Brno to Most train services, operated by Railjet, depart from Brno Hlavni Nadrazi station.
Brno to Most train services, operated by Railjet, arrive at Most station.
The distance between Brno and Most is 257.9 km. The road distance is 404 km.
You can take a train from Brno Hlavni Nadrazi to Most via Praha Hlavni Nadrazi in around 5h 37m.