The average train between Amboise and Lyon takes 6h 57m and the fastest train takes 3h 25m. The train service runs several times per day from Amboise to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Amboise and Lyon. The earliest departure is at 1:19 AM at night, and the last departure from Amboise is at 10:36 PM which arrives into Lyon at 9:30 AM. All services require a transfer, and take on average 6h 57m. The schedules shown below are for the next available departures.

8h 11m • 1 change

5h 30m • 1 change

3h 25m • 1 change

5h 48m • 1 change

7h 55m • 1 change

5h 30m • 1 change

5h 33m • 1 change

3h 55m • 1 change

8h 9m • 1 change

5h 24m • 1 change

8h 7m • 1 change
Arrives next day

10h 54m • 1 change

5h 24m • 1 change

8h 7m • 1 change
Arrives next day

10h 54m • 1 change
Want to know about travelling from Amboise to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Amboise to Lyon. However, there are services departing from Amboise station and arriving at Lyon station via Lyon Part Dieu. The journey, including transfers, takes approximately 6h 57m.
Amboise to Lyon train services, operated by Société Nationale des Chemins de fer Français (SNCF), depart from St Pierre Des Corps station.
Amboise to Lyon train services, operated by Société Nationale des Chemins de fer Français (SNCF), arrive at Lyon Part Dieu station.
Book your Amboise to Lyon train tickets online with Société Nationale des Chemins de fer Français (SNCF) and TGV inOui.
The distance between Amboise and Lyon is 348.3 km. The road distance is 659 km.
TGV inOui operates a train from St Pierre Des Corps to Lyon Part Dieu 4 times a day. Tickets cost €140–230 and the journey takes 3h 3m. Société Nationale des Chemins de fer Français (SNCF) also services this route every 4 hours.