The average bus between Tyler and Des Moines takes 23h and the fastest bus takes 20h 20m. The bus service runs several times per day from Tyler to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Tyler and Des Moines. The earliest departure is at 3:35 PM in the afternoon, and the last departure from Tyler is at 9:05 PM which arrives into Des Moines at 10:45 PM. All services require a transfer at Dallas Bus Station and take an average of 23h. The schedules shown below are for the next available departures.
Arrives next day


20h 20m • 2 changes
Arrives next day


25h 40m • 2 changes
Arrives next day


20h 20m • 2 changes
Arrives next day


25h 40m • 2 changes
Arrives next day


20h 20m • 2 changes
Arrives next day


25h 40m • 2 changes
Want to know about travelling from Tyler to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Tyler to Des Moines. However, there are services departing from Tyler station and arriving at Des Moines station via Dallas Bus Station station. The journey, including transfers, takes approximately 23h.
Tyler to Des Moines bus services, operated by Greyhound USA, depart from Tyler station.
Tyler to Des Moines bus services, operated by Greyhound USA, arrive at Des Moines station.
The distance between Tyler and Des Moines is 1,039.3 km. The road distance is 1,387 km.
You can take a bus from Tyler to Des Moines via Dallas Bus Station and Kansas City in around 18h 30m.