The average bus between Tlaxcala and Cdmx takes 2h 14m and the fastest bus takes 2h 10m. There is a bus service every few hours from Tlaxcala to Cdmx. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Tlaxcala and Cdmx. The earliest departure is at 5:00 AM in the morning, and the last departure from Tlaxcala is at 9:00 PM which arrives into Cdmx at 11:10 PM. All services require a transfer at México TAPO and take an average of 2h 14m. The schedules shown below are for the next available departures.

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Want to know about travelling from Tlaxcala to Cdmx? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Tlaxcala to Cdmx. However, there are services departing from Tlaxcala station and arriving at Cdmx station via México TAPO. The journey, including transfers, takes approximately 2h 14m.
Tlaxcala to Cdmx bus services, operated by Autobuses Supra, depart from Tlaxcala station.
Tlaxcala to Cdmx bus services, operated by Autobuses Supra, arrive at México TAPO station.
The distance between Tlaxcala and Cdmx is 100.8 km. The road distance is 118 km.
Autotransportes Tlaxcala, Apizaco, Huamantla, S.A. de C.V. operates a bus from Tlaxcala to México TAPO hourly. Tickets cost $50–270 and the journey takes 1h 30m. Autobuses Supra also services this route hourly.