The average bus between State College and St. Louis takes 20h 7m and the fastest bus takes 19h 30m. The bus service runs several times per day from State College to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between State College and St. Louis. The earliest departure is at 1:25 PM in the afternoon, and the last departure from State College is at 7:35 PM which arrives into St. Louis at 3:10 PM. All services require a transfer, and take on average 20h 7m. The schedules shown below are for the next available departures.
Arrives next day

18h 30m • 1 change
Arrives next day

19h 35m • 1 change
Arrives next day

18h 30m • 1 change
Arrives next day

19h 35m • 1 change
Arrives next day

18h 30m • 1 change
Arrives next day

19h 35m • 1 change
Arrives next day

18h 30m • 1 change
Arrives next day

20h 5m • 1 change
Want to know about travelling from State College to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from State College to St. Louis. However, there are services departing from State College station and arriving at St. Louis station via Pittsburgh Intermodal Station station. The journey, including transfers, takes approximately 20h 7m.
State College to St. Louis bus services, operated by Greyhound USA, depart from State College Bus Station.
State College to St. Louis bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Book your State College to St. Louis bus tickets online with Greyhound USA and Megabus.
The distance between State College and St. Louis is 1,081.5 km. The road distance is 1,219 km.
You can take a bus from State College Bus Station to St Louis Bus Station via Pittsburgh Intermodal Station in around 18h 40m.