The average bus between State College and St. Louis takes 24h and the fastest bus takes 21h 5m. The bus service runs several times per day from State College to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between State College and St. Louis. The earliest departure is at 6:00 AM in the morning, and the last departure from State College is at 7:05 PM which arrives into St. Louis at 3:10 PM. All services require a transfer at Pittsburgh Greyhound and take an average of 24h. The schedules shown below are for the next available departures.
Arrives next day

25h 55m • 1 change
Arrives next day

20h 5m • 1 change
Arrives next day

25h 55m • 1 change
Arrives next day

20h 5m • 1 change
Arrives next day

25h 55m • 1 change
Arrives next day

20h 5m • 1 change
Want to know about travelling from State College to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from State College to St. Louis. However, there are services departing from State College station and arriving at St. Louis station via Pittsburgh Greyhound. The journey, including transfers, takes approximately 24h.
State College to St. Louis bus services, operated by Megabus, depart from State College, Pa station.
State College to St. Louis bus services, operated by Megabus, arrive at St Louis Bus Station.
Book your State College to St. Louis bus tickets online with Megabus, Greyhound USA and Fullington Trailways.
The distance between State College and St. Louis is 1,081.5 km. The road distance is 1,191 km.
You can take a bus from State College, Pa to St Louis Bus Station via Pittsburgh Greyhound and Pittsburgh Intermodal Station in around 16h 40m.