The average bus between Southampton and Slough takes 2h 28m and the fastest bus takes 2h 8m. There is a bus service every few hours from Southampton to Slough. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Southampton and Slough. The earliest departure is at 2:05 AM at night, and the last departure from Southampton is at 8:30 PM which arrives into Slough at 10:56 PM. All services require a transfer, and take on average 2h 28m. The schedules shown below are for the next available departures.

2h 46m • 1 change

2h 31m • 1 change

2h 31m • 1 change

2h 31m • 1 change

2h 19m • 1 change

2h 18m • 1 change

2h 9m • 1 change

2h 31m • 1 change

2h 19m • 1 change

2h 18m • 1 change

2h 8m • 1 change

2h 31m • 1 change

2h 19m • 1 change

2h 20m • 1 change

2h 33m • 1 change

2h 47m • 1 change
Want to know about travelling from Southampton to Slough? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Southampton to Slough. However, there are services departing from Southampton station and arriving at Slough station via Heathrow Terminal 5. The journey, including transfers, takes approximately 2h 28m.
Southampton to Slough bus services, operated by National Express, depart from Coach Station.
Southampton to Slough bus services, operated by National Express, arrive at Landmark Place station.
Book your Southampton to Slough bus tickets online with National Express and Thames Valley Buses.
The distance between Southampton and Slough is 87.8 km. The road distance is 111 km.
You can take a bus from Coach Station to Landmark Place via Heathrow Terminal 5 in around 2h 21m.