The average bus between Slough and Southampton takes 2h 20m and the fastest bus takes 2h. There is a bus service every few hours from Slough to Southampton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Slough and Southampton. The earliest departure is at 12:00 AM at night, and the last departure from Slough is at 11:00 PM which arrives into Southampton at 1:30 AM. All services require a transfer, and take on average 2h 20m. The schedules shown below are for the next available departures.

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Want to know about travelling from Slough to Southampton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Slough to Southampton. However, there are services departing from Slough station and arriving at Southampton station via Heathrow Terminal 5. The journey, including transfers, takes approximately 2h 20m.
Slough to Southampton bus services, operated by Thames Valley Buses, depart from Wellington Street Stop A station.
Slough to Southampton bus services, operated by Thames Valley Buses, arrive at Coach Station.
Book your Slough to Southampton bus tickets online with Thames Valley Buses, National Express and First Berkshire & The Thames Valley.
The distance between Slough and Southampton is 87.8 km. The road distance is 115 km.
You can take a bus from Wellington Street Stop A to Coach Station via Heathrow Terminal 5 in around 2h 55m.