The average bus between Slough and Penzance takes 9h 23m and the fastest bus takes 8h 33m. The bus service runs several times per day from Slough to Penzance. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Slough and Penzance. The earliest departure is at 8:31 AM in the morning, and the last departure from Slough is at 10:32 PM which arrives into Penzance at 7:05 AM. All services require a transfer, and take on average 9h 23m. The schedules shown below are for the next available departures.

10h 9m • 1 change

9h 13m • 1 change

9h 53m • 1 change
Arrives next day

8h 33m • 1 change

10h 9m • 1 change

9h 13m • 1 change

9h 53m • 1 change
Arrives next day

8h 33m • 1 change

10h 9m • 1 change

9h 13m • 1 change

9h 53m • 1 change
Arrives next day

8h 33m • 1 change

10h 9m • 1 change

9h 28m • 1 change

10h 8m • 1 change
Arrives next day

8h 33m • 1 change

9h 26m • 1 change

9h 2m • 1 change

10h 6m • 1 change
Arrives next day

8h 33m • 1 change
Want to know about travelling from Slough to Penzance? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Slough to Penzance. However, there are services departing from Slough station and arriving at Penzance station via Bus Station station. The journey, including transfers, takes approximately 9h 23m.
Slough to Penzance bus services, operated by First Berkshire & The Thames Valley, depart from Heathrow Central Bus Station.
Slough to Penzance bus services, operated by First Berkshire & The Thames Valley, arrive at Bus Station.
Book your Slough to Penzance bus tickets online with First Berkshire & The Thames Valley and National Express.
The distance between Slough and Penzance is 380 km. The road distance is 484 km.
National Express operates a bus from Heathrow Central Bus Station to Bus Station 4 times a day. Tickets cost £55–130 and the journey takes 7h 50m.