The average bus between Slough and Cardiff takes 4h 12m and the fastest bus takes 3h 37m. There is a bus service every few hours from Slough to Cardiff. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Slough and Cardiff. The earliest departure is at 6:39 AM in the morning, and the last departure from Slough is at 11:32 PM which arrives into Cardiff at 4:00 AM. All services require a transfer, and take on average 4h 12m. The schedules shown below are for the next available departures.

4h 32m • 1 change

3h 55m • 1 change

4h 22m • 1 change
Arrives next day

4h 25m • 1 change

4h 21m • 1 change

4h 20m • 1 change

3h 51m • 1 change

4h 21m • 1 change

4h 21m • 1 change

4h 20m • 1 change

3h 51m • 1 change

4h 21m • 1 change

4h 21m • 1 change

4h 20m • 1 change

3h 51m • 1 change

4h 21m • 1 change
Want to know about travelling from Slough to Cardiff? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Slough to Cardiff. However, there are services departing from Slough station and arriving at Cardiff station via Sophia Gardens. The journey, including transfers, takes approximately 4h 12m.
Slough to Cardiff bus services, operated by First Berkshire & The Thames Valley, depart from Heathrow Central Bus Station.
Slough to Cardiff bus services, operated by First Berkshire & The Thames Valley, arrive at Sophia Gardens station.
Book your Slough to Cardiff bus tickets online with First Berkshire & The Thames Valley and National Express.
The distance between Slough and Cardiff is 178.9 km. The road distance is 235 km.
National Express operates a bus from Heathrow Central Bus Station to Sophia Gardens hourly. Tickets cost £26–65 and the journey takes 2h 55m.