The average bus between Siena and Prague takes 18h 36m and the fastest bus takes 17h 20m. The bus service runs several times per day from Siena to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Siena and Prague. The earliest departure is at 3:05 PM in the afternoon, and the last departure from Siena is at 6:10 PM which arrives into Prague at 1:55 PM. All services require a transfer, and take on average 18h 36m. The schedules shown below are for the next available departures.
Arrives next day
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19h 45m • 1 change
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17h 20m • 1 change
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19h 45m • 1 change
Arrives next day
Arrives next day

17h 20m • 1 change
Arrives next day

19h 45m • 1 change
Arrives next day

17h 20m • 1 change
Arrives next day

19h 45m • 1 change
Arrives next day
Arrives next day

17h 20m • 1 change
Arrives next day

19h 45m • 1 change
Want to know about travelling from Siena to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Siena to Prague. However, there are services departing from Siena station and arriving at Prague station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 18h 36m.
Siena to Prague bus services, operated by FlixBus, depart from Siena station.
Siena to Prague bus services, operated by FlixBus, arrive at Praha, ÚAN Florenc station.
Book your Siena to Prague bus tickets online with FlixBus and RegioJet.
The distance between Siena and Prague is 788.6 km. The road distance is 1,085 km.
You can take a bus from Siena to Praha, ÚAN Florenc via Florence Villa Constanza Bus Station in around 16h 55m.