The bus between Siena and Palermo takes 16h. There is at least one bus per day from Siena to Palermo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Siena and Palermo. The earliest departure is at 7:00 PM in the evening, and the last departure from Siena is at 7:00 PM which arrives into Palermo at 11:00 AM. All services run direct with no transfers required, and take on average 16h. The schedules shown below are for the next available departures.
Want to know about travelling from Siena to Palermo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
Yes, there is a direct bus departing from Siena station and arriving at Palermo station. Services depart once daily, and operate Once daily. The journey takes approximately 16h.
Siena to Palermo bus services, operated by FlixBus, depart from Siena station.
Siena to Palermo bus services, operated by FlixBus, arrive at Palermo station.
Book your Siena to Palermo bus tickets online with FlixBus.
The distance between Siena and Palermo is 600.9 km. The road distance is 1,209 km.
FlixBus operates a bus from Siena to Palermo once daily. Tickets cost €80–140 and the journey takes 16h.