The average bus between Santa Ana and Irwindale takes 6h 57m and the fastest bus takes 4h 30m. The bus service runs several times per day from Santa Ana to Irwindale. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Santa Ana and Irwindale. The earliest departure is at 7:40 AM in the morning, and the last departure from Santa Ana is at 9:25 PM which arrives into Irwindale at 7:05 AM. All services require a transfer at Los Angeles Union Station and take an average of 6h 57m. The schedules shown below are for the next available departures.


4h 31m • 2 changes


7h 34m • 2 changes
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8h 31m • 2 changes


4h 30m • 2 changes


7h 36m • 2 changes
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8h 31m • 2 changes


4h 30m • 2 changes


7h 36m • 2 changes
Arrives next day


8h 31m • 2 changes


4h 30m • 2 changes


7h 36m • 2 changes
Arrives next day


8h 31m • 2 changes


4h 30m • 2 changes


7h 36m • 2 changes
Arrives next day


8h 31m • 2 changes
Want to know about travelling from Santa Ana to Irwindale? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santa Ana to Irwindale. However, there are services departing from Santa Ana station and arriving at Irwindale station via Los Angeles Union Station station. The journey, including transfers, takes approximately 6h 57m.
Santa Ana to Irwindale bus services, operated by Greyhound USA, depart from Santa Ana Bus Stop station.
Santa Ana to Irwindale bus services, operated by Greyhound USA, arrive at Arrow Hwy and Irwindale Ave E station.
The distance between Santa Ana and Irwindale is 40.7 km. The road distance is 112 km.
You can take a bus from Santa Ana Bus Stop to Arrow Hwy and Irwindale Ave E via Los Angeles Union Station, El Monte Bus Stop, and El Monte Station Upper Level in around 3h 47m.