The average bus between Santa Ana and Irwindale takes 4h 50m and the fastest bus takes 2h 11m. The bus service runs several times per day from Santa Ana to Irwindale. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Santa Ana and Irwindale. The earliest departure is at 9:10 AM in the morning, and the last departure from Santa Ana is at 9:20 PM which arrives into Irwindale at 7:07 AM. All services require a transfer at Los Angeles Union Station and take an average of 4h 50m. The schedules shown below are for the next available departures.


2h 41m • 2 changes


2h 57m • 2 changes
Arrives next day


8h 36m • 2 changes


2h 41m • 2 changes


2h 57m • 2 changes
Arrives next day


8h 36m • 2 changes


2h 41m • 2 changes


2h 57m • 2 changes
Arrives next day


8h 36m • 2 changes


2h 41m • 2 changes


2h 57m • 2 changes
Arrives next day


8h 36m • 2 changes
Want to know about travelling from Santa Ana to Irwindale? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santa Ana to Irwindale. However, there are services departing from Santa Ana station and arriving at Irwindale station via Los Angeles Union Station station. The journey, including transfers, takes approximately 4h 50m.
Santa Ana to Irwindale bus services, operated by Greyhound Mexico, depart from Santa Ana station.
Santa Ana to Irwindale bus services, operated by Greyhound Mexico, arrive at West Covina Pkwy and California Ave E station.
The distance between Santa Ana and Irwindale is 40.7 km. The road distance is 90 km.
You can take a bus from Santa Ana to Irwindale Ave and Arrow Hwy N via Los Angeles Union Station, Union Station Patsaouras Bus Plaza E, West Covina Pkwy and California Ave E, and West Covina Pkwy and California Ave W in around 2h 30m.