Rome2Rio

Rome to Santander buses

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Trip Overview

The bus between Rome and Santander takes 45h 40m. The bus runs, on average, 5 times per week from Rome to Santander. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

45h 40m
Duration
1,984 km
Distance
€182
Average price
5 times a week
Frequency

Rome to Santander bus times

Buses run 5 times a week between Rome and Santander. The earliest departure is at 11:40 AM in the morning, and the last departure from Rome is at 11:40 AM which arrives into Santander at 7:20 AM. All services require a transfer at Florence Villa Constanza Bus Station and take an average of 45h 40m. The schedules shown below are for the next available departures.

Departing Thursday, October 15, 2026

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    Arrives +2 days

    FlixBusFlixBusFlixBus45h 40m • 2 changes

Departing Friday, October 16, 2026

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    Arrives +2 days

    FlixBusFlixBusFlixBus45h 40m • 2 changes

Departing Saturday, October 17, 2026

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    Arrives +2 days

    FlixBusFlixBusFlixBus45h 40m • 2 changes

Departing Sunday, October 18, 2026

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    Arrives +2 days

    FlixBusFlixBusFlixBus45h 40m • 2 changes

Departing Monday, October 19, 2026

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    Arrives +2 days

    FlixBusFlixBusFlixBus45h 40m • 2 changes

Frequently asked questions

Want to know about travelling from Rome to Santander? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Rome to Santander.ExpandLaunch map view
  • Distance: 1,983.9 km
  • Duration: 45h 40m

What companies run services between Rome, Italy and Santander, Spain?

You can take a bus from Roma, Autostazione Tiburtina to Estación de autobuses de Santander via Florence Villa Constanza Bus Station and Bordeaux in around 28h 30m.

Operators