The average bus between Rome and Otranto takes 10h 46m and the fastest bus takes 9h 28m. The bus service runs several times per day from Rome to Otranto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Rome and Otranto. The earliest departure is at 6:50 AM in the morning, and the last departure from Rome is at 11:45 PM which arrives into Otranto at 11:12 AM. All services require a transfer, and take on average 10h 46m. The schedules shown below are for the next available departures.
Arrives next day

9h 28m • 1 change
Arrives next day

11h 27m • 1 change

10h 15m • 1 change

11h 5m • 1 change
Arrives next day

9h 28m • 1 change
Arrives next day

11h 27m • 1 change

11h 5m • 1 change
Arrives next day

9h 28m • 1 change
Arrives next day

11h 27m • 1 change

10h 15m • 1 change

11h 5m • 1 change
Arrives next day

9h 28m • 1 change
Arrives next day

11h 27m • 1 change

10h 15m • 1 change

11h 5m • 1 change
Arrives next day

9h 28m • 1 change
Arrives next day

11h 27m • 1 change
Want to know about travelling from Rome to Otranto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome to Otranto. However, there are services departing from Rome station and arriving at Otranto station via Lecce. The journey, including transfers, takes approximately 10h 46m.
Rome to Otranto bus services, operated by FlixBus, depart from Roma, Autostazione Tiburtina station.
Rome to Otranto bus services, operated by FlixBus, arrive at Otranto - Stazione FSE station.
Book your Rome to Otranto bus tickets online with FlixBus and Salento in bus.
The distance between Rome and Otranto is 538.5 km. The road distance is 664 km.
You can take a bus from Roma, Autostazione Tiburtina to Otranto - Stazione FSE via Lecce - City Terminal in around 11h 2m.