The average bus between Rome and Lucerne takes 14h 24m and the fastest bus takes 12h 20m. The bus service runs several times per day from Rome to Lucerne. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Rome and Lucerne. The earliest departure is at 12:15 AM at night, and the last departure from Rome is at 3:45 PM which arrives into Lucerne at 2:20 AM. All services require a transfer, and take on average 14h 24m. The schedules shown below are for the next available departures.

14h 10m • 1 change
Arrives next day

12h • 1 change
Arrives next day

10h 35m • 1 change

14h 10m • 1 change
Arrives next day

12h • 1 change
Arrives next day

10h 35m • 1 change

14h 10m • 1 change

12h 20m • 1 change
Arrives next day

12h • 1 change
Arrives next day

10h 35m • 1 change

14h 10m • 1 change
Arrives next day

12h • 1 change
Arrives next day

11h 35m • 1 change
Want to know about travelling from Rome to Lucerne? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome to Lucerne. However, there are services departing from Rome station and arriving at Lucerne station via Luzerner Raststätte A2. The journey, including transfers, takes approximately 14h 24m.
Rome to Lucerne bus services, operated by FlixBus, depart from Roma Prenestina A1 station.
Rome to Lucerne bus services, operated by FlixBus, arrive at Luzerner Raststätte A2 station.
Book your Rome to Lucerne bus tickets online with FlixBus, Itabus S.p.A. and RegioJet.
The distance between Rome and Lucerne is 662 km. The road distance is 867 km.
Onebus operates a bus from Roma Prenestina A1 to Luzerner Raststätte A2 once a week, and the journey takes 6h 57m.