The average bus between Rome and Agnone takes 6h 26m and the fastest bus takes 3h 45m. The bus service runs several times per day from Rome to Agnone. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Rome and Agnone. The earliest departure is at 11:15 AM in the morning, and the last departure from Rome is at 9:00 PM which arrives into Agnone at 7:50 AM. All services require a transfer, and take on average 6h 26m. The schedules shown below are for the next available departures.

3h 45m • 1 change

4h 15m • 1 change

4h 50m • 1 change
Arrives next day

13h 20m • 1 change

3h 45m • 1 change

4h 15m • 1 change

4h 50m • 1 change
Arrives next day

13h 20m • 1 change

3h 45m • 1 change

4h 15m • 1 change

4h 50m • 1 change
Arrives next day

13h 20m • 1 change
Want to know about travelling from Rome to Agnone? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome to Agnone. However, there are services departing from Rome station and arriving at Agnone station via Isernia. The journey, including transfers, takes approximately 6h 26m.
Rome to Agnone bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., depart from Roma, Autostazione Tiburtina station.
Rome to Agnone bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., arrive at Agnone station.
The distance between Rome and Agnone is 155.7 km. The road distance is 216 km.
You can take a bus from Roma, Autostazione Tiburtina to Agnone via Isernia in around 4h.