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Presque Isle to Indianapolis buses

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Trip Overview

The average bus between Presque Isle and Indianapolis takes 39h 11m and the fastest bus takes 32h 35m. The bus runs, on average, 5 times per week from Presque Isle to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

39h 11m
Duration
1,436 mi
Distance
$274
Average price
5 times a week
Frequency

Presque Isle to Indianapolis bus times

Buses run 5 times a week between Presque Isle and Indianapolis. The service departs Presque Isle at 7:25 AM in the morning, which arrives into Indianapolis at 16:00:00. All services require a transfer at Bangor, ME and take an average of 39h 11m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

  •  → 

    Arrives next day

    Cyr Bus LineAmtrak ThruwayFlixbus USAFlixbus USA32h 35m • 3 changes

Departing Tuesday, November 10, 2026

  •  → 

    Arrives +2 days

    Cyr Bus LineAmtrak ThruwayFlixbus USAFlixbus USA43h 35m • 3 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Cyr Bus LineAmtrak ThruwayFlixbus USAFlixbus USA43h 35m • 3 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Cyr Bus LineAmtrak ThruwayFlixbus USAFlixbus USA43h 35m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Cyr Bus LineAmtrak ThruwayFlixbus USAFlixbus USA32h 35m • 3 changes

Frequently asked questions

Want to know about travelling from Presque Isle to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Presque Isle to Indianapolis.ExpandLaunch map view
  • Distance: 1,435.9 mi
  • Duration: 39h 11m

What companies run services between Presque Isle, ME, USA and Indianapolis, IN, USA?

You can take a bus from Presque Isle, Maine to Indianapolis via Bangor, ME, Bangor Transportation Center, Boston, MA - South Station, Boston, and New York Midtown in around 30h 47m.

Operators